Cage culture is a system in which fish, enclosed in a cage, are raised in aquatic resources. Factors such as increasing aquatic animals consumption among the population and reducing the natural reserves of some species, shortages and resource constraints, and reducing the income and economic value of production in ponds have led growers to recover traditional practices and have a strong motivation in manufacturers to produce fish in cages. One of the fish major problem in in cage culture is infectious diseases and easy transmission of these. Yearly damage to the fish industry comes from a variety of diseases, and manufacturers have taken antibiotics to fight diseases. Using long-term antibiotics in aquaculture, in addition to creating enormous environmental problems, can lead to antibiotic resistance in the bacterial flora of water resources and further damage to aquaculture. Therefore, the methods that were based on the prevention of the disease became more noticeable. One of the ways to prevent diseases is vaccination. The purpose of this study is to summarize important pathogens in cage culture and develop vaccines as an alternative to antibiotics to protect them.
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